Transcription profiling of human alveolar macrophages from phenotypically normal smokers compared to non-smokers to identify new genes linking to early events in the molecular pathogenesis of COPD

ABSTRACT: Cigarette smoking is the leading cause of the respiratory diseases collectively known as chronic obstructive pulmonary disease (COPD). While the pathogenesis of COPD is complex, there is abundant evidence that alveolar macrophages (AM) play an important role. Based on the concept that COPD is a slow-progressing disorder likely involving multiple mediators released by AM activated by cigarette smoke, the present study focuses on the identification of previously unrecognized genes that may be linked to early events in the molecular pathogenesis of COPD, as opposed to factors associated with the presence of disease. To accomplish this, microarray analysis using Affymetrix microarrays was used to carry out an unbiased survey of the differences in gene expression profiles in the AM of phenotypi

ORGANISM(S): Homo sapiens

SUBMITTER: Adriana Heguy 

PROVIDER: E-GEOD-3212 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress