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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Mycobacterium avium subsp. paratuberculosis gene transcription in simulated phagosomal environment and in human macrophage infection

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE32241: Differentially regulated genes induced in Mycobacterium avium subspecies paratuberculosis by in vitro acid-nitrosative multi-stress GSE32242: Differentially regulated genes induced in Mycobacterium avium subspecies paratuberculosis by in vitro infection of THP-1 human macrophage cell line Refer to individual Series

ORGANISM(S): Mycobacterium avium subsp. paratuberculosis

SUBMITTER: Andrea Cossu

PROVIDER: E-GEOD-32243 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression profiling of Mycobacterium avium subsp. paratuberculosis in simulated multi-stress conditions and within THP-1 cells reveals a new kind of interactive intramacrophage behaviour.

Cossu Andrea A Sechi Leonardo Antonio LA Zanetti Stefania S Rosu Valentina V

BMC microbiology 20120530

<h4>Background</h4>Recent studies have identified in Mycobacterium avium subsp. paratuberculosis (MAP), already known as a pathogen in ruminants, a potential zoonotic agent of some autoimmune diseases in humans. Therefore, considering the possible risk for public health, it is necessary a thorough understanding of MAP's gene expression during infection of human host as well as the identification of its immunogenic and/or virulence factors for the development of appropriate diagnostic and therape ...[more]

PMID: 22646160

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Differentially regulated genes induced in Mycobacterium avium subspecies paratuberculosis by in vitro infection of THP-1 human macrophage cell line

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2012-05-31 | E-GEOD-32242 | biostudies-arrayexpress

Differentially regulated genes induced by in vitro generated Mycobacterium avium subspecies paratuberculosis cell wall deficient forms

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2012-11-29 | E-GEOD-32235 | biostudies-arrayexpress

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Project description:Transcriptional profile of Mycobacterium avium subspecies paratuberculosis in in vitro acid-nitrosative multistress, comparing untreated control cells and bacteria under multi-stress. Two-condition experiment, MAP-K vs. MAP-ACID-NO treated. Biological replicates: 3 controls, 3 Acid-NO treated, independently grown and harvested. In controls and Acid-NO treated cells, good quality RNA samples obtained from each pellet were pooled together and used for microarray experiments to get an average of three separate experiments, four replicates per array.

2012-05-31 | E-GEOD-32241 | biostudies-arrayexpress

Transcriptional profile of pathogenic and non-pathogenic in vitro generated mycobacterial cell wall deficient forms

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2012-11-29 | E-GEOD-32237 | biostudies-arrayexpress

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2012-11-29 | E-GEOD-32236 | biostudies-arrayexpress

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2013-11-05 | E-GEOD-34623 | biostudies-arrayexpress

Signal Regulatory Protein Beta 2 is a novel positive regulator of innate anticancer immunity, GFP-IP/MS of SIRP-B2 on THP-1

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2023-12-04 | PXD047166 | Pride

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