Regulation of monocyte functional heterogeneity by miR-146a

ABSTRACT: Monocytes and their lineage descendants serve as a central defense system against infection and injury but if uncontrolled can also promote an excessive pathological inflammatory response. Therefore a current research goal is to understand how the organism controls the number and function of monocytes and how these variables can be tailored in therapy. Considering the evidence that monocytes are heterogeneous and exist in at least two subsets committed to divergent functions, we investigated whether distinct factors regulate the balance between monocyte subset responses in vivo. We identified a microRNA (miRNA), miR-146a, which is differentially regulated both in mouse (Ly-6Chi and Ly-6Clo) and human (CD14hi and CD14lo CD16+) monocyte subsets. The single miRNA was found to significantly co

ORGANISM(S): Mus musculus

SUBMITTER: Martin Etzrodt 

PROVIDER: E-GEOD-32370 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress