Multifaceted neuro-regenerative activities of human dental stem cells promote locomotor recovery after complete transection of the rat spinal cord

ABSTRACT: Spinal cord injury (SCI) often leads to persistent functional deficits due to severe neuron and glial loss, and to limited axonal regeneration after injury. Here we show that the transplantation of human dental stem cells into the completely transected adult rat spinal cord resulted in a significant recovery of hindlimb locomotor functions. These stem cells exhibited three major neuro-regenerative activities. First, they inhibited the SCI-induced apoptosis of neurons, astrocytes, and oligodendrocytes, improving the preservation of neuronal filaments and myelin sheaths. Second, they promoted the regeneration of transected axons by directly inhibiting multiple axon growth inhibitors, including chondroitin sulfate proteoglycan and myelin-associated glycoprotein, by paracrine mechanisms. Third

ORGANISM(S): Homo sapiens

SUBMITTER: Akihito Yamamoto 

PROVIDER: E-GEOD-32403 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress