Stable gene expression of serial skin biopsies defines patient subsets in diffuse cutaneous systemic sclerosis

ABSTRACT: Systemic sclerosis (SSc) shows complex clinical manifestations including progressive skin and internal organ fibrosis. SSc can be divided into 'intrinsic subsets' by gene expression suggesting patient-specific heterogeneity in pathogenesis or temporal evolution of disease. Here we validate these subsets using an independent patient population, and test whether the genes vary over time with patients changing subsets as disease progresses, or if the genes are a stable feature of the patients within each subset. Skin biopsies were analyzed from 13 dSSc patients enrolled in an open label study of rituximab, 9 dSSc patients not treated with rituximab, and 9 healthy controls. These data recapitulate the patient 'intrinsic subsets' described previously with gene expression associated with cell p

ORGANISM(S): Homo sapiens

SUBMITTER: Michael Whitfield 

PROVIDER: E-GEOD-32413 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress