Analysis of M-OM-^CL dependent traits based on phenotypic and transcriptomic evaluation of the Listeria monocytogenes EGDe strain

ABSTRACT: The phenotypic and gene expression traits conferred by the alternative sigma factor protein M-OM-^CL in the food-borne pathogen L. monocytogenes were investigated. M-OM-^CL was shown to be important for the efficient growth of this pathogen exposed to food preservative measures such as low storage temperatures, elevated osmolarity and acidity. Based on high throughput phenotypic analysis, M-OM-^CL function was also found to be protective in L. monocytogenes EGDe cells exposed to several antimicrobial compounds including some of the antibiotics currently applied in listeriosis treatment. The expression of flagella genes and motility were significantly compromized upon loss of M-OM-^CL function. A comparative transcriptome analysis of exponential growth EGDe wild type and sigL null cells un

ORGANISM(S): Listeria monocytogenes EGD-e

SUBMITTER: Panu Somervuo 

PROVIDER: E-GEOD-32434 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress