Multicilin promotes centriole assembly and ciliogenesis during multiciliate cell differentiation.

ABSTRACT: Analysis of epithelial explants injected with the intracellular domain of Notch (ICD) alone, to block the formation of multiciliate cells, or with Dexamethasone inducible Multicilin (MCI-HGR) to induce the formation of ectopic multiciliate cells. MCI-HGR plus ICD injected samples were compared to ICD alone to identify candidate genes whose expression changes when MCI is active. Epithelial cells projecting hundreds of motile cilia are prominent in the respiratory system, brain ependyma and female reproductive tract where they generate a vigorous fluid flow along luminal surfaces. Despite their importance for organ function, how multiciliate cells arise developmentally in diverse epithelia is poorly understood. We identified a novel coiled-coil protein, we have termed multicilin (MCI), who

ORGANISM(S): Xenopus laevis

SUBMITTER: Chris Kintner 

PROVIDER: E-GEOD-32452 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress