Transcription profiling of wild type and Rpe65-/- mouce retinae to characterize gene response in Rpe65-/- mouse model of Lebers congenital amaurosis during progression of the disease.

ABSTRACT: To characterize gene response in RPE65-/- mouse model of Leber's congenital amaurosis during progression of the disease, we analyzed differential gene expression in retinae early in the development of the disease, namely before and at the onset of photoreceptor cell death in knock-out mice of 2, 4 and 6 months of age. Experiment Overall Design: We compared gene expression in wild type and RPE65-/- retinae at 2, 4 and 6 months of age. Three biological replicates were performed for each of the six conditions analyzed; this series hence contains 18 samples.

ORGANISM(S): Mus musculus

SUBMITTER: Lydia Michaut 

PROVIDER: E-GEOD-3249 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress