Specific Lineage differentiation of proepicardial explant cultures

ABSTRACT: The HH16/17 chicken proepicardium (PE) gives rise to the embryonic epicardium (Epi) which significantly contributes formation of the coronary vasculature during cardiac development. In contrast to explanted Epi cells, explanted PE cells can undergo differentiation into a cardiac myocyte phenotype. In order to assess which genes are associated with PE differentiation into distinc cellular lineages, three interconnented microarray gene-expression time series were performed at time 0, 24, 72 and 120h after incubation with specific growth conditions: 1: Bmp2 + U0126: differentiation towards a cardiomyocyte phenotype 2: F2f2 + Vegf: differentiation towards a vascular epithelial phenotype 3: Fgf2: differentiation towards a epicardial phenotype Gene-expression profiles were determined by hybridiz

ORGANISM(S): Gallus gallus

SUBMITTER: Henk Buermans 

PROVIDER: E-GEOD-32508 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress