Dataset Information
Transcription profiling of diaphragm muscles from alpha2-laminin (merosin)-deficient dy/dy dystrophic mice and wild type mice to study differential gene expression.
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Erik -- van Lunteren
PROVIDER: E-GEOD-3252 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Gene expression profiling of diaphragm muscle in alpha2-laminin (merosin)-deficient dy/dy dystrophic mice.
Physiological genomics 20051220 1
Deficiency of alpha2-laminin (merosin) underlies classical congenital muscular dystrophy in humans and dy/dy muscular dystrophy in mice and causes severe muscle dysfunction in both species. To gain greater insight into the biochemical and molecular events that link alpha2-laminin deficiency with muscle fiber necrosis, and the associated compensatory responses, gene expression profiles were characterized in diaphragm muscle from 8-wk-old dy/dy mice using oligonucleotide microarrays. Compared with ...[more]
