Molecular phenotyping of the idiopathic interstitial pneumonias [miRNA]

ABSTRACT: Rationale: The fibrosing idiopathic interstitial pneumonias (IIPs) are classified based on clinical, radiographic, and pathologic criteria. The separation into phenotypic subgroups is useful in predicting outcome and therapeutic strategy; however a large degree of ambiguity remains. Gene expression profiling may contribute to traditional criteria in IIPs by characterizing the dynamic biology that more accurately distinguishes subtypes of these diseases or their prognoses. Methods: We collected transcriptional and miRNA profiles on lung tissue from 167 subjects with IIP and 50 non-diseased controls. Differential expression of individual transcripts and miRNAs was identified using an ANCOVA model incorporating the clinical diagnosis of each subject as well as age, gender, and smoking status

ORGANISM(S): Homo sapiens

SUBMITTER: Ivana Yang 

PROVIDER: E-GEOD-32538 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress