Midbrain floor plate dopamine neurons from human ESCs efficiently engraft in murine and primate models of PD

ABSTRACT: Human pluripotent stem cells (hPSCs) are a promising source of cells for applications in regenerative medicine. Directed differentiation of hPSCs into specialized cells such as spinal motoneurons or midbrain dopamine (DA) neurons has been achieved. However the effective use of hPSCs for cell therapy has lagged far behind. While mouse PSC-derived DA neurons have shown efficacy in models of Parkinson’s disease, DA neurons derived from human PSCs generally display poor in vivo performance. There are also considerable safety concerns for hPSCs related to their potential for teratoma formation or neural overgrowth. Here we present a novel floor plate-based strategy for the derivation of human DA neurons that efficiently engraft, suggesting that past failures were due to incomplete specificatio

ORGANISM(S): Homo sapiens

SUBMITTER: Jeffrey Zhao 

PROVIDER: E-GEOD-32658 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress