The impact of aging on memory T cell phenotype and function in the human bone marrow

ABSTRACT: Recently, the bone marrow (BM) has been shown to play a key role in regulating the survival and function of memory T cells. However, the impact of aging on these processes has not yet been studied. We demonstrate that the number of CD4+ and CD8+ T cells in the BM is maintained during aging. However, the composition of the T cell pool in the aged BM is altered with a decline of naïve and an increase in effector-memory T cells. In contrast to the peripheral blood (PB), a highly activated CD8+CD28– T cell population, which lacks the late differentiation marker CD57, accumulates in the BM of elderly persons. IL-6 and IL-15, which are both increased in the aged BM, efficiently induce the activation, proliferation and differentiation of CD8+ T cell in vitro, highlighting a role of these cytokine

ORGANISM(S): Homo sapiens

SUBMITTER: Dietmar Herndler-Brandstetter 

PROVIDER: E-GEOD-32725 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress