Transcription profiling of human leukocytes after an inflammatory stimulus (bacterial endotoxin) to identify significant functional modules perturbed in response to this stimulus using network analysis

ABSTRACT: Oligonucleotide and complementary DNA microarrays are being used to subclassify histologically similar tumours, monitor disease progress, and individualize treatment regimens. However, extracting new biological insight from high-throughput genomic studies of human diseases is a challenge, limited by difficulties in recognizing and evaluating relevant biological processes from huge quantities of experimental data. Here we present a structured network knowledge-base approach to analyse genome-wide transcriptional responses in the context of known functional interrelationships among proteins, small molecules and phenotypes. This approach was used to analyse changes in blood leukocyte gene expression patterns in human subjects receiving an inflammatory stimulus (bacterial endotoxin). We explor

ORGANISM(S): Homo sapiens

SUBMITTER: IDDC Inflammation the Host Response to Injury 

PROVIDER: E-GEOD-3284 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress