Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression

ABSTRACT: Lung cancer is the leading cause of cancer death worldwide and adenocarcinoma is its most common histological subtype. Clinical and molecular evidence indicates that lung adenocarcinoma is a heterogeneous disease, which has important implications for treatment. Here we performed genome-scale DNA methylation profiling using the Illumina Infinium HumanMethylation27 platform on 59 matched lung adenocarcinoma/non-tumor lung samples, with genome-scale verification on an independent set of tissues. We identified 766 genes showing altered DNA methylation between tumors and non-tumor lung. By integrating DNA methylation and mRNA expression data, we identified 164 hypermethylated genes showing concurrent downregulation, and 57 hypomethylated genes showing increased expression. Integrated pathways

ORGANISM(S): Homo sapiens

SUBMITTER: Ite Laird-Offringa 

PROVIDER: E-GEOD-32861 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress