Synthetic double stranded RNA reliably induces innate immunity similar to a live viral vaccine in humans

ABSTRACT: Adjuvants are critical for the success of vaccines, and agonists for microbial pattern recognition receptors are promising new candidates. A mechanism for the immune enhancing role of adjuvants is to stimulate innate immunity. We studied the innate immune response in humans to synthetic double stranded RNA (poly ICLC), a ligand for TLR3 and MDA-5 cytosolic RNA helicase. Transcriptional analysis of blood samples from eight volunteers, after subcutaneous administration of poly ICLC showed upregulation of genes involved in multiple innate immune pathways in all subjects, including interferon and inflammasome signaling. Blocking of type I interferon receptor ex vivo significantly dampened the response to poly IC. Comparative transcriptional analysis showed that several innate pathways were sim

ORGANISM(S): Homo sapiens

SUBMITTER: Ali Filali 

PROVIDER: E-GEOD-32862 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress