Discover preclinical biomarkers of hepatotoxicity: Acetaminophen and Carbon tetrachloride

ABSTRACT: Preclinical biomarkers useful for identification of idiosyncratic drugs have not been identified. It is hypothesized that patterns of transcript expression for the hepatotoxicants, including classical and idiosyncratic hepatotoxicants, are similar and the patterns differ from those of non-hepatotoxicants. This experiment is part of the biomarkers study, and focus on two clasical hepatotoxicants: Acetaminophen and Carbon tetrachloride. We have employed whole genome microarray expression profiling to identify liver gene expression changes induced by hepatotoxicants. For the same animal, urinary microRNA profiling were analyzed. APAP and CCl4 both significantly increased the urinary levels of 44 and 28 miRNAs, respectively. In addition, 10 of the increased miRNAs were in common between APAP

ORGANISM(S): Rattus norvegicus

SUBMITTER: Zhenqiang Su 

PROVIDER: E-GEOD-32891 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress