A Molecular Taxonomy of Urothelial Carcinoma

ABSTRACT: Even though urothelial cancer (UC) is the fourth common tumor type among males, progress in treatment development has been deficient. Pathological assessment provides the urologists with only a broad classification, complicated by frequent disagreement among pathologist and the co-existence of different grading systems. Consequently, there is a great need for an objective, reproducible and biologically relevant classification system to make treatment more efficient. In the present investigation we present a molecular taxonomy for UC stratification based on integrated genomics. We used gene expression profiles from 308 UC to define seven molecular subtypes using step-by-step partitions and a bootstrap approach. Results were validated in three independent and publically available data sets.

ORGANISM(S): Homo sapiens

SUBMITTER: Gottfrid Sjodahl 

PROVIDER: E-GEOD-32894 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress