Genome-wide transcriptional profiling of the cell envelope stress response of Listeria monocytogenes

ABSTRACT: The Gram-positive bacterium Listeria monocytogenes is widely distributed in the environment and capable of causing food-borne infections in susceptible individuals. In this study, we investigated the cell envelope stress response in L. monocytogenes. Whole-genome transcriptional profiling was performed to investigate the response upon exposure to the cell wall antibiotic cefuroxime. Differential expression (≥ 2-fold difference) of 558 genes was observed, corresponding to 20% of the L. monocytogenes genome. The majority of genes strongly induced by cefuroxime exposure have cell envelope-related functions, including the dlt-operon, genes encoding penicillin-binding proteins, and members from the LiaRS regulon. The virulence-associated genes dacA and lmo2714 were up-regulated upon cefuroxime

ORGANISM(S): Listeria monocytogenes

SUBMITTER: Maarten Mols 

PROVIDER: E-GEOD-32913 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress