Natural variation in processability of individual Arabidopsis thaliana microRNAs

ABSTRACT: Like protein coding genes, loci that produce microRNAs (miRNAs) are generally considered to be under purifying selection, consistent with miRNA polymorphisms being able to cause disease. Nevertheless, it has been hypothesized that variation in miRNA genes may contribute to phenotypic diversity. Here we demonstrate that a naturally occurring polymorphism in the MIR164A gene interacts epistatically with an unlinked locus to affect leaf shape and shoot architecture in Arabidopsis thaliana. A single-base pair substitution in the miRNA complementary sequence alters the stability of the miRNA:miRNA* duplex. It thereby interferes with processing of the precursor and greatly reduces miRNA accumulation. We demonstrate that this is not a rare exception, but that natural strains of Arabidopsis thalia

ORGANISM(S): Arabidopsis thaliana

SUBMITTER: Felix Ott 

PROVIDER: E-GEOD-32927 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress