Transcription profiling of gallbladders from mice treated with leptin or saline to test the hypothesis that leptin would alter gallbladder gene expression

ABSTRACT: Gallstone disease is a major contributor to health care costs in the United States. Approximately 12 % of the U.S. population has gallstones. As a result, more than 700,000 cholecystectomies are performed in this country each year. Many of these patients are obese and have a positive family history; but surprisingly, little is known about the link between obesity, genetics and gallstone formation. Obese individuals have been shown to have supersaturated bile, larger gallbladder fasting volumes and impaired gallbladder emptying. We have recently demonstrated that leptin plays a role in gallbladder motility. In an effort to understand the genetic basis for these observations, we tested the hypothesis that leptin would alter gallbladder gene expression. Methods: Affymetrix oligonucleo

ORGANISM(S): Mus musculus

SUBMITTER: Henry Pitt 

PROVIDER: E-GEOD-3293 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress