The Expression of MicroRNA and microRNA Clusters in the Aging Heart

ABSTRACT: Adult aging is a complex biological process associated with altered gene expression and a decline in physiological performance. The microRNAs have been implicated in cardiac development, cardiac hypertrophy and heart failure. However, the impact of adult aging on cardiac expression of both miRNA guide strand (miR) and passenger strand (miR*), as well as miRNA clusters have not been well established. We explored the expression profile of both miR and miR* in the heart. We found that 65 miRNAs were differentially expressed in old versus young adult heart; approximately half of them were clustered miRNAs that were distributed in 11 miRNA clusters. Each miRNA cluster contains from 2 to as many as 71 miRNA genes. The majority of the clusters displayed unified expression, with most cluster me

ORGANISM(S): Mus musculus

SUBMITTER: Jeanne Wei 

PROVIDER: E-GEOD-32935 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress