IGF1-receptor signalling attenuates the age-related decline of diastolic cardiac function

ABSTRACT: Insulin-like growth factor (IGF1R) signalling has been implicated to play an important role in regulation of cardiac growth, hypertrophy and contractile function, and has been linked to the development of age related congestive heart failure. Here we address the question to what extent cardiomyocyte specific IGF1 signalling is essential for maintenance of the structural and functional integrity of the adult murine heart. To investigate the effects of IGF1 signalling in the adult heart without confounding effects due to IGF1 over-expression or adaptation during embryonic and early post-natal development, we inactivated the IGF1R by a 4-hydroxy tamoxifen inducible Cre recombinase in adult cardiac myocytes. Efficient inactivation of the IGF1R (iCMIGF1RKO) as assessed by Western analysis and r

ORGANISM(S): Mus musculus

SUBMITTER: Antje Lindecke 

PROVIDER: E-GEOD-32936 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress