Gene expression profiling of laparoscopic donor nephrectomy samples compared to healthy control kidneys

ABSTRACT: We compared gene expression profiles from six donor kidneys prior to surgical manipulation to six kidneys removed after laparoscopic donor nephrectomy (LDN) and several hours of CO2 pneumoperitoneum. Biopsies were obtained from renal cortex and hybridized to Affymetrix HG-U133A GeneChips. For control kidneys we identified 1380 genes present on all 6 samples that had a signal intensity greater than 1000. Functional classification of these revealed genes for cellular signaling (201; 15%), regulation of transcription (156; 11%), cellular transport (144; 10%) and cellular metabolism (111; 8%). A class comparison between the controls and LDN kidneys yielded 865 differentially expressed genes. Functional classification of the 502 genes differentially up-regulated in LDN kidneys identified a

ORGANISM(S): Homo sapiens

SUBMITTER: Sunil Kurian 

PROVIDER: E-GEOD-3297 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress