Dynamic transcriptomes during human erythroid differentiation and development

ABSTRACT: To explore the mechanisms controlling erythroid differentiation and development in human, we analyzed the genome-wide transcription dynamics that occurs during the differentiation of HESCs into the erythroid lineage and development of embryonic to adult erythropoiesis using high throughput sequencing technology. Undifferentiated HESCs as well as erythroid cells at three developmental stages-ESER (embryonic stage), FLER (fetal stage) and PBER (adult stage)-were analyzed. Our findings revealed that the number of expressed genes decreased during the differentiation, while the total expression intensity increased. At the 3 transitions (HESC-ESER, ESER-FLER and FLER-PBER), differential expression of many types of genes was observed at every transition. These differentially expressed genes were

ORGANISM(S): Homo sapiens

SUBMITTER: yadong yang 

PROVIDER: E-GEOD-32991 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress