E. coli response to MMC

ABSTRACT: Changes in gene expression after treatment of E. coli cultures with mitomycin C were assessed using gene array technology. Unexpectedly, a large number of genes (nearly 30% of all genes) displayed significant changes in their expression level. Analysis and classification of expression profiles of the corresponding genes allowed us to assign this large number of genes into a dozen to two dozen small clusters of genes with similar expression profiles. This assignment allowed us to describe systematically the changes in the level of gene expression in response to DNA damage. Among the damage-induced genes more than a hundred are novel. From those genes involved in DNA metabolism that have not been previously shown to be induced by DNA damage, for example, the mutS gene involved in mismatc

ORGANISM(S): Escherichia coli

SUBMITTER: Natalya Smirnova 

PROVIDER: E-GEOD-33 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress