Form deprivation modulates retinal neurogenesis in primate experimental myopia

ABSTRACT: Juvenile primates develop myopia when their visual experience is degraded by lid fusion. In response to the abnormal visual input, retinal neural networks cause an excessive growth of the postequatorial segment of the eye, but the mechanism underlying this axial elongation is unknown. By combining analysis of gene expression, injection of the thymidine analog 5-bromo-2'-deoxyuridine and immunocytochemistry, we show that the retinal periphery in both juvenile rhesus macaques and green monkeys harbors a population of mitotically active neuroprogenitor cells that proliferate when the visual experience is altered by lid fusion. Furthermore, the number of dividing cells is highly correlated with the axial elongation of the eye and the resulting myopic refractive error. Thus, the retina undergoe

ORGANISM(S): Macaca mulatta

SUBMITTER: Pamela Walsh 

PROVIDER: E-GEOD-3300 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress