Effects of corn oil gavage on gene expression profiles of thymus in Wistar Rats

ABSTRACT: To investigate the effects of corn oil (CO), common drug vehicle, on the gene expression profiles in rat thymus with microarray technique. Female Wistar Rats were administered daily with normal saline (NS), CO 2, 5, 10 ml/kg for 14 days, respectively. Then, the thymus samples of rats were collected for microarray test and histopathology examination. The microarray data showed that 0, 40, 458 differentially expressed genes (DEGs) in 2, 5, 10 ml/kg CO group compared to NS group, respectively. The altered genes were associated with immune response, cellular response to organic cyclic substance, regulation of fatty acid beta-oxidation, et al. However, no obvious histopathologic change was observed in the three CO dosage groups. These data show that 10 ml/kg CO , that dosage has been determin

ORGANISM(S): Rattus norvegicus

SUBMITTER: Hong Weiguo 

PROVIDER: E-GEOD-33005 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress