Chromosome positioning and the clustering of functionally related loci in yeast is driven by chromosomal interactions

ABSTRACT: In recent years there has been considerable and growing interest in the 3-dimensional organization of genomes. In yeast this has included detailed FISH studies that show a surprising degree of spatial clustering of the tRNA genes, the localization of telomeres, centromere positioning, and global studies of chromosomal interactions.M-BM- In this study we performed an integrated biophysical M-bM-^@M-^S molecular study to produce the first high-resolution 3-dimensional reconstruction of a eukaryotic genome from first principles. Our conformations were produced using a using a molecular dynamics simulator to model the 16 yeast chromosomes as individual polymers. Critically, the compaction, folding and spatial organization of these chromosomes was informed by empirical data determined using pro

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Justin O'Sullivan 

PROVIDER: E-GEOD-33018 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress