PU.1 restricts adult hematopoietic stem cell proliferation via cell specific autoregulation

ABSTRACT: To guarantee blood supply throughout adult life hematopoietic stem cells (HSCs) need to carefully balance between self-renewing cell divisions and quiescence. Identification of genes controlling HSC self-renewal is of utmost importance given that HSCs are the only stem cells with broad clinical applications. Transcription factor PU.1 is one of the major regulators of myeloid and lymphoid development. Recent reports suggest that PU.1 mediates its functions via gradual expression level changes rather than binary on/off states. So far, this has not been considered in any study of HSCs and thus, PU.1’s role in HSC function has remained largely unclear. Here we demonstrate using hypomorphic mice with an engineered disruption of an autoregulatory feedback loop that decreased PU.1 levels resulted

ORGANISM(S): Mus musculus

SUBMITTER: Henry Yang 

PROVIDER: E-GEOD-33031 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress