Developmental time-course of adult cell-type-specific retina genes of amacrine cells

ABSTRACT: Brain circuits are assembled from a large variety of morphologically and functionally diverse cell types. It is not known how the intermingled cell types of individual brain regions differ in their expressed genomes. Here we describe an atlas of cell type transcriptomes of the adult retina. We found that each adult cell type expresses a specific set of genes, including a unique set of transcription factors, forming a “barcode” for cell identity. Cell type transcriptomes carry enough information to categorize cells into corresponding morphological classes and types. Surprisingly, several barcode genes are eye disease-associated genes that we demonstrate to be specifically expressed not only in photoreceptors but also in particular retinal circuit elements such as inhibitory neurons as well

ORGANISM(S): Mus musculus

SUBMITTER: Sandra Siegert 

PROVIDER: E-GEOD-33088 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress