Transcription profiling of rat posterior cricoarytenoid muscle from animals aged 6, 18 and 30 months

ABSTRACT: Sarcopenia is the decreased muscle mass and weakness associated with aging and a major cause of morbidity and mortality in the elderly. To what extent non-locomotive muscles are susceptible to this condition is unclear. For example, age affects laryngeal function (ventilation, airway protective reflexes, swallowing and phonation). Age-related laryngeal dysfunction may be due to effects on its intrinsic muscles that have a unique phenotype: very small, mostly fast oxidative muscle fibers. For this study, we examined how age alters the functional characteristics and gene expression profile of posterior cricoarytenoid (PCA), an intrinsic laryngeal muscle. PCA muscles from Fischer 344-Brown Norway F1 hybrid rats (6 and 30 months of age) were used for cDNA microarrays, light and electron (EM) m

ORGANISM(S): Rattus norvegicus

SUBMITTER: Colleen McMullen 

PROVIDER: E-GEOD-3310 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress