The amniotic fluid transcriptome: a source of novel information about human fetal development

ABSTRACT: Amniotic fluid (AF) is a complex biological material that provides a unique window into the developing human. Residual AF supernatant contains cell-free fetal RNA. The objective of this study was to develop an understanding of the AF core transcriptome by identifying the transcripts ubiquitously present in the AF supernatant of euploid midtrimester fetuses. We detected 476 well-annotated genes present in all twelve AF samples. Functional analysis identified 6 physiological systems represented in the AF core transcriptome, including musculoskeletal and nervous system development and function and embryonic/ organismal development. mTOR signaling was identified as a key canonical pathway. Twenty-three highly organ-specific transcripts were identified; six of these are known to be highly expre

ORGANISM(S): Homo sapiens

SUBMITTER: Donna Slonim 

PROVIDER: E-GEOD-33168 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress