Anti-IFN antibody 16 array set
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Cheryl Hemingway
PROVIDER: E-GEOD-3319 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Acquired predisposition to mycobacterial disease due to autoantibodies to IFN-gamma.
Kampmann Beate B Hemingway Cheryl C Stephens Alick A Davidson Robert R Goodsall Anna A Anderson Suzanne S Nicol Mark M Schölvinck Elisabeth E Relman David D Waddell Simon S Langford Paul P Sheehan Brian B Semple Lynn L Wilkinson Katalin A KA Wilkinson Robert J RJ Ress Stanley S Hibberd Martin M Levin Michael M
The Journal of clinical investigation 20050825 9
Genetic defects in the IFN-gamma response pathway cause unique susceptibility to intracellular pathogens, particularly mycobacteria, but are rare and do not explain mycobacterial disease in the majority of affected patients. We postulated that acquired defects in macrophage activation by IFN-gamma may cause a similar immunological phenotype and thus explain the occurrence of disseminated intracellular infections in some patients without identifiable immune deficiency. Macrophage activation in re ...[more]
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