Protein coding gene expression profile of dasatinib-treated chronic myeloid leukemia patients with resistance to imatinib

ABSTRACT: Dasatinib has demonstrated efficacy in patients with chronic-phase chronic myeloid leukemia (CML) who had resistance or intolerance to imatinib. However, some patients also develop resistance or intolerance to dasatinib. To identify potential molecular pathways involved in primary resistance to dasatinib in CML, we analyzed gene expression profiles of mononuclear cells of 7 imatinib-resistant patients, collected before and after 1-year dasatinib treatment. Large-scale gene expression was measured with Agilent microarrays covering protein-coding genes and long (>200 nt) noncoding RNAs (lncRNAs). Sets of genes and lncRNAs significantly differentially expressed (>1.5 fold-change; q value ?10%) were identified. Ingenuity Pathway Analysis pointed to a number of functions, canonical pathways and

ORGANISM(S): Homo sapiens

SUBMITTER: Angela Fachel 

PROVIDER: E-GEOD-33224 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress