Nla18/DK1622

ABSTRACT: NtrC-like activators regulate transcription of a wide variety of adaptive genes in bacteria. Previously we demonstrated that a mutation in the NtrC-like activator gene nla18 severely inhibits M. xanthus fruiting body development and vegetative growth. In this study, we found that inactivation of nla18 has dramatic effects on gene expression patterns during development and vegetative growth. Gene expression in nla18 cells is altered in the early stages of fruiting body development. In addition, nla18 cells are defective for two of the earliest events in development, production of the intracellular starvation signal ppGpp and production of A-signal. Taken together, these results indicate that the developmental program in nla18 cells goes awry very early. Inactivation nla18 also causes a

ORGANISM(S): Myxococcus xanthus

SUBMITTER: Mitchell Singer 

PROVIDER: E-GEOD-3323 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress