SRNA profiles of control adults, postdauer adults, larva L3, and dauer stages of C. elegans

ABSTRACT: Early environmental experiences and life histories profoundly influence adult phenotypes via as yet poorly understood mechanisms. We previously showed that wild-type adult C. elegans that transiently passed through the stress-induced dauer larval stage (post-dauers) exhibit different gene expression patterns, genome-wide chromatin structure, and life history traits when compared to adults that bypassed the dauer stage (controls). Here we show that endogenous small inhibitory RNAs (endo-siRNAs) and siRNA pathways may mediate developmental history-dependent phenotypic diversity. Deep sequencing of small RNA libraries show changes in endo-siRNA levels in post-dauer as compared to control animals, and meta analyses indicate that specific endo-siRNA pathways are targets of developmental history

ORGANISM(S): Caenorhabditis elegans

SUBMITTER: Nelson Lau 

PROVIDER: E-GEOD-33313 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress