The Rho Exchange Factors Vav2 and Vav3 Control a Lung MetastasisM-bM-^@M-^SSpecific Transcriptional Program in Breast Cancer Cells

ABSTRACT: The guanosine triphosphatases of the Rho and Rac subfamilies regulate protumorigenic pathways and are activated by guanine nucleotide exchange factors (Rho GEFs), which could be potential targets for anticancer therapies. We report that two Rho GEFs, Vav2 and Vav3, play synergistic roles in breast cancer by sustaining tumor growth, neoangiogenesis, and many of the steps involved in lung-specific metastasis. The involvement of Vav proteins in these processes did not correlate with Rac1 and RhoA activity or cell migration, implying the presence of additional biological programs. Microarray analyses revealed that Vav2 and Vav3 controlled a vast transcriptional program in breast cancer cells through mechanisms that were shared between the two proteins, isoform-specific or synergistic. Furtherm

ORGANISM(S): Mus musculus

SUBMITTER: RamM-CM-3n GarcM-CM--a-Escudero 

PROVIDER: E-GEOD-33348 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress