CD99 is a novel prognostic stromal marker in non-small cell lung cancer

ABSTRACT: The delicate interaction between cancer cells and the surrounding stroma plays an essential role in all stages of tumourigenesis. Despite the significance of this interplay, alterations in protein composition underlying tumour-stroma interactions are largely unknown. The aim of this study was to identify stromal proteins with clinical relevance in non-small cell lung cancer. A list encompassing 203 stromal candidate genes was compiled based on gene expression array data and available literature. The protein expression of these genes in human NSCLC was screened utilising the Human Protein Atlas. Twelve proteins were selected that showed a differential stromal staining pattern. The corresponding antibodies were applied on a tissue microarray, including 190 NSCLC samples, and stromal staining

ORGANISM(S): Homo sapiens

SUBMITTER: Anders Isaksson 

PROVIDER: E-GEOD-33363 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress