Hypothalamic gene expression profile indicates a reduction in G-protein signaling in the wfs1 mutant mice

ABSTRACT: WFS1 gene is coding protein with unknown function but its functional deficiency causes different neuropsychiatric and neuroendocrine syndromes. In the present study we aimed to find the functional networks influenced by the Wfs1 deficiency in the hypothalamus. We performed gene expression profiling (Mouse Gene 1.0 ST Arrays) in Wfs1 deficient mice (ko). Modified t-statistics was used for comparison of groups (wt vs ko). Functional annotation of the alterations in RNA levels was performed with Ingenuity Pathway Analysis. 305 genes were differentially expressed with nominal p-value less than 0.01. FDR adjusted p-values were significant (0.007) only for two genes M-bM-^@M-^S C4b (t=9.66) and Wfs1 (t=-9.03). However, several genes related to the G-protein signalling were very close to the FDR

ORGANISM(S): Mus musculus

SUBMITTER: Sulev Koks 

PROVIDER: E-GEOD-33372 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress