Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Expression data from healthy human CD161++CD8aa and CD161++CD8ab T cells

ABSTRACT: We used microarrays to compare gene expression between healthy human CD161++CD8aa and CD161++CD8ab T cells. We sorted freshly obtained peripheral blood mononucleocytes from healthy controls by first using magnetic beads to negatively select for CD8a+ T cells, fluorescently labelling isolated cells with antibodies and subsequent sorting using MoFlow MLS cell sorter (DAKO). Sorted samples were snap frozen. RNA was later extracted from the sorted populations prior to hybridization to Affymetrix arrays.

ORGANISM(S): Homo sapiens

SUBMITTER: Natasha Sahgal

PROVIDER: E-GEOD-33374 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Human MAIT and CD8αα cells develop from a pool of type-17 precommitted CD8+ T cells.

Walker Lucy J LJ Kang Yu-Hoi YH Smith Matthew O MO Tharmalingham Hannah H Ramamurthy Narayan N Fleming Vicki M VM Sahgal Natasha N Leslie Alistair A Oo Ye Y Geremia Alessandra A Scriba Thomas J TJ Hanekom Willem A WA Lauer Georg M GM Lantz Olivier O Adams David H DH Powrie Fiona F Barnes Eleanor E Klenerman Paul P

Blood 20111115 2

Human mucosal associated invariant T (MAIT) CD8(+) and Tc17 cells are important tissue-homing cell populations, characterized by high expression of CD161 ((++)) and type-17 differentiation, but their origins and relationships remain poorly defined. By transcriptional and functional analyses, we demonstrate that a pool of polyclonal, precommitted type-17 CD161(++)CD8αβ(+) T cells exist in cord blood, from which a prominent MAIT cell (TCR Vα7.2(+)) population emerges post-natally. During this expa ...[more]

PMID: 22086415

Dataset Information

Expression data from healthy human CD161++CD8aa and CD161++CD8ab T cells

Publications

Human MAIT and CD8αα cells develop from a pool of type-17 precommitted CD8+ T cells.

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