Gene expression analysis of osteosarcoma tumor-initiating cells (High) vs bulk tumor cells (Low)

ABSTRACT: In the cancer stem cell model a cell hierarchy has been suggested as an explanation for intratumoral heterogeneity, and tumor formation is thought to be driven by this tumor cell subpopulation. The identification of cancer stem cells in osteosarcoma (OS) and the biological processes dysregulated in this cell subpopulation, also known as tumor-initiating cells (TICs), may provide new therapeutic targets. The goal of this study, therefore, was to identify and characterize the gene expression profiles of TICs isolated from human OS cell lines. We analyzed the self-renewal capacity of OS cell lines and primary OS tumors based upon their ability to form sphere-like structures (sarcospheres) under serum-starving conditions. TICs were identify from OS cell lines using the long-term label retentio

ORGANISM(S): Homo sapiens

SUBMITTER: Alexander Yu 

PROVIDER: E-GEOD-33458 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress