Corelation between RISC complex, LINE-1 RNA and Global hypomethylation in head and Neck cancer cell line.

ABSTRACT: One of most common events in carcinogenesis is loss of DNA methylation (hypomethylation) from sequence of transposable element (TEs) including long interspersed nuclear element-1 (LINE-1). Naturally, LINE-1 and other TEs within gene body region (intragenic) will suppress by fully methylated CpG sequences in order to keep prevent incorrect transcriptional start site (TSSs) that cause genome instability. To study character of intragenic LINE-1 promoter hypomethylation or gene body methylation status, within Head and Neck squamous cell carcinoma (HNSCC) cell, LINE-1 promoter methylation status was detected with CU-L1 (unique intragenic LINE-1) and COBRALINE-1 (whole genome LINE- 1) PCRs. Each intragenic LINE-1 promoter hypomethylation have unique pattern depending on cell types and impact of

ORGANISM(S): Homo sapiens

SUBMITTER: Chureerat Phokaew 

PROVIDER: E-GEOD-33493 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress