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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression data on lungs of wild-type and Rora (Retinoic acid related orphan receptor) mutant mice exposed to room air and smoke

ABSTRACT: Gene expression data on wild-type and Rora mutant mice exposed to room air and smoke. The results provide a general insight into the relationship of Rora to known DNA damage response pathways and its role in cigarette smoke-induced airspace enlargement. This dataset includes 4 wild-type mice exposed to room air, 4 wild-type mice exposed to cigarette smoke and 4 Rora mutant mice exposed to cigarette smoke.

ORGANISM(S): Mus musculus

SUBMITTER: Kusum Pandit

PROVIDER: E-GEOD-33512 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Retinoic acid-related orphan receptor-α is induced in the setting of DNA damage and promotes pulmonary emphysema.

Shi Ying Y Cao Jiaofei J Gao Jane J Zheng Liang L Goodwin Andrew A An Chang Hyoek CH Patel Avignat A Lee Janet S JS Duncan Steven R SR Kaminski Naftali N Pandit Kusum V KV Rosas Ivan O IO Choi Augustine M K AM Morse Danielle D

American journal of respiratory and critical care medicine 20120628 5

<h4>Rationale</h4>The discovery that retinoic acid-related orphan receptor (Rora)-α is highly expressed in lungs of patients with COPD led us to hypothesize that Rora may contribute to the pathogenesis of emphysema.<h4>Objectives</h4>To determine the role of Rora in smoke-induced emphysema.<h4>Methods</h4>Cigarette smoke extract in vitro and elastase or cigarette smoke exposure in vivo were used to model smoke-related cell stress and airspace enlargement. Lung tissue from patients undergoing lun ...[more]

PMID: 22744720

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