T cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling

ABSTRACT: Although transcriptional programs associated with T-cell specification and commitment have been described, the functional hierarchy and the roles of key regulators in structuring/ orchestrating these programs remain unclear. Activation of Notch signaling in uncommitted precursors by the thymic stroma initiates the T-cell differentiation program. One regulator first induced in these precursors is the DNA binding protein Tcf-1, a T-cell specific mediator of Wnt signaling. Yet the specific contribution of Tcf-1 to early T-cell development and the signals inducing it in these cells remain unclear. Here we assign functional significance to Tcf-1 as a gatekeeper of T-cell fate. We show that Tcf-1 is directly activated by Notch signals. Tcf-1 is required at the earliest phase of Tcell determinati

ORGANISM(S): Mus musculus

SUBMITTER: Jiangwen Zhang 

PROVIDER: E-GEOD-33513 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress