Analysis of miRNA profiles in CD4+ T-lymphocytes following exposure to HIV-1

ABSTRACT: Assessment of the extent to which the altered profiles of miRNA expression influence viral replication and latency, as well as the efficiency of host defenses, may be useful for understanding the basis of the HIV-1-related alterations in cellular physiology and immunologic control. To this end, three patient groups were enrolled. One group consisted of subjects who were classified as M-CM-)lite control long-term non-progressors (M-CM-)LTNP). A second study group was HIV-1-positive subjects, who were antiretroviral therapy naive. A third group was multiply exposed to HIV-1, but uninfected (MEU). This study allowed us to investigate the existence of a CD4+T- lymphocytes miRNAs signature able to discriminate among different stages of HIV-1 infection, and to evaluate whether the exposure to

ORGANISM(S): Homo sapiens

SUBMITTER: Claudio Casoli 

PROVIDER: E-GEOD-33514 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress