Normal breast tissue of obese women is enriched for macrophage markers and macrophage-associated gene expression

ABSTRACT: Activation of inflammatory pathways is one plausible mechanism underlying the association between obesity and increased breast cancer risk. However, macrophage infiltration and local biomarkers of inflammation in breast adipose tissue have seldom been studied in association with obesity. Gene expression profiles of normal breast tissue from reduction mammoplasty patients were evaluated by whole genome microarrays to identify patterns associated with obesity status (normal-weight, body mass index (BMI) <25; overweight, BMI 25-29.9; obese, BMI > or equal to 30). The presence of macrophage-enriched inflammatory loci with immunopositivity for CD68 protein was evaluated by immunohistochemistry (IHC). After adjusting for confounding by age, 760 genes were differentially expressed (203 up and 557

ORGANISM(S): Homo sapiens

SUBMITTER: Melissa Troester 

PROVIDER: E-GEOD-33526 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress