Transcription profiling of rat aortic rings treated with angiopoietin-1, VEGF or untreated

ABSTRACT: Specific Aims ; To identify novel transcriptional events associated with angiogenesis in VEGF and Ang-1 stimulated rat aortic rings. Our studies take advantage of the capacity of rat aortic rings to generate new vessels in collagen gels. Rat aortic rings embedded in collagen gel immediately after excision from the animal produce a self-limited angiogenic response under serum-free conditions and in the absence of exogenous stimuli. This angiogenic response can be dose-dependently promoted by vascular endothelial growth factor (VEGF) and angiopoietin-1 (Ang-1), which are critical regulators of the angiogenic process during embryonal development and postnatal angiogenesis. Aortic rings lose their capacity to spontaneously generate new vessels if embedded in collagen gels 10-14 days after e

ORGANISM(S): Rattus norvegicus

SUBMITTER: Alfred Aplin 

PROVIDER: E-GEOD-3355 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress