Ontology highlight
ABSTRACT:
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: Audrey Gasch
PROVIDER: E-GEOD-3358 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Gasch A P AP Huang M M Metzner S S Botstein D D Elledge S J SJ Brown P O PO
Molecular biology of the cell 20011001 10
Eukaryotic cells respond to DNA damage by arresting the cell cycle and modulating gene expression to ensure efficient DNA repair. The human ATR kinase and its homolog in yeast, MEC1, play central roles in transducing the damage signal. To characterize the role of the Mec1 pathway in modulating the cellular response to DNA damage, we used DNA microarrays to observe genomic expression in Saccharomyces cerevisiae responding to two different DNA-damaging agents. We compared the genome-wide expressio ...[more]