Massage therapy attenuates NFκB nuclear accumulation and inflammatory cytokine production following damage in human skeletal muscle

ABSTRACT: Massage therapy is commonly used for the physical rehabilitation of skeletal muscle to ameliorate pain and promote recovery from injury. While there is some evidence that massage may relieve pain in injured muscle, the cellular effects remain unknown. To assess the effects of massage, we administered either massage therapy or no treatment to separate quadriceps of eleven young, male participants after exercised-induced muscle damage. Muscle biopsies were acquired from the quadriceps (vastus lateralis) at baseline (rest), immediately after 10 minutes of massage treatment (0h), and after a 2.5 hour period of recovery. We found that massage activated the mechanotransduction signaling pathways FAK and Erk1/2, potentiated mitochondrial biogenesis signaling (nuclear PGC-1α), and mitigated the r

ORGANISM(S): Homo sapiens

SUBMITTER: Simon Melov 

PROVIDER: E-GEOD-33603 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress